Ortho-AP1867 free base

AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12 F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG…

For research use only. Not for human or veterinary use.

Target FKBP Ligands for Target Protein for PROTAC

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Ortho-AP1867 structure

CAS No.: 2230613-03-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 500.00	BP-00726-100mg	In stock	Get quote
250 mg	USD 898.00	BP-00726-250mg	In stock	Get quote
500 mg	USD 1,600.00	BP-00726-500mg	In stock	Get quote
1 g	Inquire	BP-00726-1g	In stock	Inquire
2 g	Inquire	BP-00726-2g	In stock	Inquire

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Description

AP1867-2-(carboxymethoxy), the AP1867 (a synthetic FKBP12 F36V-directed ligand) based moiety, binds to CRBN ligand via a linker to form dTAG molecules .

Biological activity

In Vitro dTAG molecules engage FKBP12F36V and CRBN

Identifiers

SMILES: O=C(O)COC1=CC=CC=C1[C@H](OC([C@H]2N(C([C@H](C3=CC(OC)=C(OC)C(OC)=C3)CC)=O)CCCC2)=O)CCC4=CC=C(OC)C(OC)=C4
InChIKey: UYXSZUBFOQLRNQ-BTIIJPOSSA-N

Specifications

MW (average): 693.7799
Formula: C₃₈H₄₇NO₁₁
CAS No.: 2230613-03-1
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: —

Solubility

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441.

Same target

Search FKBP

Same research area

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