Selpercatinib free base · Synonyms: LOXO-292

Selpercatinib is a RET kinase inhibitor.

For research use only. Not for human or veterinary use.

Target RET

Research area Cancer

Purity >99% Stock Inquire

Data Sheet SDS COA

Selpercatinib structure

CAS No.: 2152628-33-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
2 g	USD 380.00	BP-01975-2g	In stock	Get quote
3 g	USD 450.00	BP-01975-5g	In stock	Get quote
5 g	USD 950.00	BP-01975-10g	In stock	Get quote
10 g	USD 1,500.00	BP-01975-25g	In stock	Get quote

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Description

Selpercatinib (LOXO-292) is a RET kinase inhibitor.

Biological activity

In Vivo Selpercatinib (LOXO-292; 10 mg/kg; i.g.; for 0-2 h) has good pharmacokinetics after oral gavage in FVB/NRj mice.

Identifiers

SMILES: COC1=CC=C(CN2C3CC2CN(C3)C2=CC=C(C=N2)C2=CC(OCC(C)(C)O)=CN3N=CC(C#N)=C23)C=N1
InChIKey: XIIOFHFUYBLOLW-UHFFFAOYSA-N

Specifications

MW (average): 525.6015
Formula: C₂₉H₃₁N₇O₃
CAS No.: 2152628-33-4
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Şentürk R, et, al. Quantitative bioanalytical assay for the selective RET inhibitors selpercatinib and pralsetinib in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Jun 15;1147:122131.

[2]. Steven W. Andrews, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1.

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