SMARCA-BD ligand 1 for Protac free base

SMARCA-BD ligand 1 for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC[1].

For research use only. Not for human or veterinary use.

Target Ligands for Target Protein for PROTAC SWI/SNF Complex

Research area Cancer

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Data Sheet SDS COA

SMARCA-BD ligand 1 for Protac structure

CAS No.: 1997319-92-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
500 mg	USD 250.00	BP-02194-500mg	In stock	Get quote
1 g	USD 380.00	BP-02194-1g	In stock	Get quote
2 g	USD 610.00	BP-02194-2g	In stock	Get quote
3 g	USD 720.00	BP-02194-3g	In stock	Get quote
5 g	USD 980.00	BP-02194-5g	In stock	Get quote
10 g	USD 1,560.00	BP-02194-10g	In stock	Get quote

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Description

SMARCA-BD ligand 1 for PROTAC is a compound that binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC[1].

Biological activity

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Identifiers

SMILES: OC1=CC=CC=C1C2=NN=C(N)C(N3CCNCC3)=C2
InChIKey: SZKHGLTYXIDOFH-UHFFFAOYSA-N

Specifications

MW (average): 271.3177
Formula: C₁₄H₁₇N₅O
CAS No.: 1997319-92-2
Physical state: Solid
Color: Light yellow to light brown
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

soluble in DMSO

Documents

References

[1]. Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.

Same target

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Same research area

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