TSPO ligand-1 free base
TSPO ligand-1 is the ligand of AUTAC4.
For research use only. Not for human or veterinary use.
TSPO ligand-1 structure
CAS No.: 4560-08-1
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 250 mg | USD 480.00 | BP-02161-250mg | In stock | Get quote |
| 500 mg | USD 750.00 | BP-02161-500mg | Inquire | Get quote |
| 1 g | USD 1,200.00 | BP-02161-1g | Inquire | Get quote |
| 2 g | USD 1,950.00 | BP-02161-2g | In stock | Get quote |
| 3 g | USD 2,800.00 | BP-02161-3g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
TSPO ligand-1 is the ligand of AUTAC4 that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal.
Biological activity
In Vitro TSPO ligand-1 gene is induced to increase expression in the context of selective activation of neurons in male C57Bl6/N mice. Moreover, neuronal activation under physiological and psychopharmacological conditions also results in increased TSPO levels in adult mice. TSPO ligand-1 can serve as the sole marker of glial cell activity in Alzheimer’s disease thus tracking the formation of different neural cells. TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus effects mitochondrial energy homeostasis in MA-10 Leydig cell line.
Identifiers
- SMILES
-
O=C(C(C1=C(C2=CC=CC=C2)NC3=C1C=CC=C3)=O)Cl - InChIKey
-
DREHVYWKTXGDBS-UHFFFAOYSA-N
Specifications
- MW (average)
- 283.7090
- Formula
- C16H10ClNO2
- CAS No.
- 4560-08-1
- Physical state
- Solid
- Color
- Light yellow to green yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃, protect from light, stored under nitrogen; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO