Leucettine L41 free base

Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinases.

For research use only. Not for human or veterinary use.

Target DYRK CDK GSK-3 Apoptosis Reactive Oxygen Species (ROS)

Research area Neurological Disease Metabolic Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

Leucettine L41 structure

CAS No.: 1112978-84-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 610.00	BP-02182-100mg	In stock	Get quote
250 mg	USD 1,240.00	BP-02182-250mg	In stock	Get quote
500 mg	USD 1,970.00	BP-02182-500mg	In stock	Get quote
1 g	USD 3,150.00	BP-02182-1g	In stock	Get quote
2 g	Inquire	BP-02182-2g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

Leucettine L41 is a potent inhibitor of dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs) and CDC-like kinases (CLKs). Leucettine L41 can also inhibit GSK-3 singnaling. Leucettine L41 can inhibit cell apoptosis and ROS production. Leucettine L41 can promote β-cell cell cycle progression, cell proliferation and increase insulin secretion. Leucettine L41 can be used for the researches of neurological disease and metabolic disease, such as Alzheimer’s disease (AD) and diabetes .

Biological activity

In Vitro Leucettine L41 (0.01-100 μM) increases viability and proliferation in MIN6 cells. Leucettine L41 (5 μM, 24 h) increases cells in G2/M phase in MIN6 cells. Leucettine L41 (5 μM, 24 h) increases insulin and C-peptide production in MIN6 cells. Leucettine L41 improves insulin secretion in isolated mouse islets. In Vivo Leucettine L41 (0.4-4 μg, i.c.v.) prevents memory deficits and neurotoxicity in Aβ25-35-treated mice.

Identifiers

SMILES: O=C1NC(NC2=CC=CC=C2)=N/C1=C\C3=CC=C(OCO4)C4=C3
InChIKey: PGPHHJBZEGSUNE-JYRVWZFOSA-N

Specifications

MW (average): 307.3034
Formula: C₁₇H₁₃N₃O₃
CAS No.: 1112978-84-3
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;

Solubility

soluble in DMSO

Documents

References

[1]. Naert G, et al. Leucettine L41, a DYRK1A-preferential DYRKs/CLKs inhibitor, prevents memory impairments and neurotoxicity induced by oligomeric Aβ25-35 peptide administration in mice. Eur Neuropsychopharmacol. 2015 Nov;25(11):2170-82.

[2]. Pucelik B, et al. DYRK1A inhibitors leucettines and TGF-β inhibitor additively stimulate insulin production in beta cells, organoids, and isolated mouse islets. PLoS One. 2023 May 17;18(5):e0285208.

Same target

Search DYRK

Same research area

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