TAK-071 free base · Synonyms: TAK 071 · TAK071
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 positive allosteric modulator.
For research use only. Not for human or veterinary use.
TAK-071 structure
CAS No.: 1820812-16-5
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 460.00 | BP-00047-100mg | In stock | Get quote |
| 250 mg | USD 860.00 | BP-00047-250mg | In stock | Get quote |
| 500 mg | USD 1,360.00 | BP-00047-500mg | In stock | Get quote |
| 1 g | USD 2,160.00 | BP-00047-1g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC50 of TAK-071 M1R agonist activities is 520 nM .
Biological activity
In Vivo TAK-071 increase hippocampal inositol monophosphate production through M1R activation and improved DB00747 -induced cognitive deficits in rats at 0.3 mg/kg. TAK-071 also induce diarrhea at 10 mg/kg in rats. Combining sub-effective doses of TAK-071 (3 mg/kg) with an acetylcholinesterase inhibitor significantly ameliorates DB00747-induced cognitive deficits in rats.
Identifiers
- SMILES
-
O=C1C=2C(CN1[C@@H]3[C@@H](O)CCOC3)=C(F)C(C)=C(CC4=CC=C(C=C4)N5C=CC=N5)C2 - InChIKey
-
WFSARWQASFQZMG-VXKWHMMOSA-N
Specifications
- MW (average)
- 421.4641
- Formula
- C24H24FN3O3
- CAS No.
- 1820812-16-5
- Physical state
- Solid
- Color
- white to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder 4℃, sealed storage, away from moisture, 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO