CU-CPT-9a free base
CU-CPT-9a is a specific TLR8 antagonist.
For research use only. Not for human or veterinary use.
CU-CPT-9a structure
CAS No.: 2165340-32-7
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 250 mg | USD 420.00 | BP-01979-250mg | In stock | Get quote |
| 500 mg | USD 685.00 | BP-01979-500mg | In stock | Get quote |
| 1 g | USD 985.00 | BP-01979-1g | In stock | Get quote |
| 5 g | Inquire | BP-01979-5g | Inquire | Inquire |
Need another size or custom synthesis? Request a quote.
Description
CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.
Biological activity
In Vitro CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5±0.1 nM. The elevation of the downstream protein levels induced by R848 can be reversed by CU-CPT-9a in a dose-dependent manner. By contrast, the expression of TRIF and IRF3 (cytoplasmic and nuclear) are only responsive to TLR4 and TLR3, independent of TLR837. The expression levels of TRIF and IRF3 do not show significant change in THP-1 cells upon treatment of R848, nor do they change with the treatment of CU-CPT-9a. CU-CPT8m and CU-CPT-9a both significantly suppress the TNF-α level in a dose-dependent manner, which is in agreement with previous reports of TLR8 involvement in these autoimmune diseases.
Identifiers
- SMILES
-
COC1=CC=C2C(=C1)N=CC=C2C1=CC(C)=C(O)C=C1 - InChIKey
-
HNYBTVKYLVLWCB-UHFFFAOYSA-N
Specifications
- MW (average)
- 265.3065
- Formula
- C17H15NO2
- CAS No.
- 2165340-32-7
- Physical state
- Solid
- Color
- light yellow to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO