CU-CPT-9b free base
CU-CPT9b is a specific TLR8 antagonist.
For research use only. Not for human or veterinary use.
CU-CPT-9b structure
CAS No.: 2162962-69-6
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 500 mg | USD 450.00 | BP-01977-500mg | In stock | Get quote |
| 1 g | USD 680.00 | BP-01977-1g | In stock | Get quote |
| 5 g | Inquire | BP-01977-5g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
CU-CPT9b is a specific TLR8 antagonist, with an IC50 of 0.7 nM. CU-CPT9b shows high binding affinity towards TLR8 with a Kd of 21 nM.
Biological activity
In Vitro CU-CPT9b is a specific TLR8 antagonist, with an IC50 of 0.7±0.2 nM. ITC experiments have confirmed the strong binding of CU-CPT9b with a Kd of 21 nM. It is shown that CU-CPT-9b binds to the inactive TLR8 dimer in a similar way to CU-CPT8m. CU-CPT9b utilizes hydrogen bonds with G351 and V520*, which are conserved among TLR8/antagonist structures. Additionally, CU-CPT9b forms water-mediated contacts with S516* and Q519*, which are not observed in TLR8/CU-CPT8m structure, suggesting that the enhanced potency of CU-CPT9b derives from the new interactions with these polar residues. The orientation of Y567* also changes to facilitate van der Waals interactions with CU-CPT9b as compared to TLR8/CU-CPT8m.
Identifiers
- SMILES
-
CC1=CC(=CC=C1O)C1=CC=NC2=CC(O)=CC=C12 - InChIKey
-
QXFYDRYRLOHSBD-UHFFFAOYSA-N
Specifications
- MW (average)
- 251.2799
- Formula
- C16H13NO2
- CAS No.
- 2162962-69-6
- Physical state
- Solid
- Color
- White to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO