Melflufen hydrochloride salt form · hydrochloride · Parent Melflufen
Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent.
For research use only. Not for human or veterinary use.
Description
Melflufen (Melphalan flufenamide) hydrochloride, a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen hydrochloride shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen hydrochloride induces irreversible DNA damage and cytotoxicity in MM cells .
Biological activity
In Vitro Melflufen (Melphalan flufenamide) hydrochloride (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner. ? Melflufen hydrochloride induces apoptosis in MM.1S cells. ? Melflufen hydrochloride also is a potent activator of exosome secretion. In Vivo Melflufen (Melphalan flufenamide) hydrochloride (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model.
Identifiers
- SMILES
-
O=C(OCC)[C@H](CC1=CC=C(F)C=C1)NC([C@H](CC2=CC=C(N(CCCl)CCCl)C=C2)N)=O.[H]Cl - InChIKey
-
ZCMWSKHHXLCVHI-VROPFNGYSA-N
Specifications
- MW (average)
- 534.8790
- Formula
- C24H31Cl3FN3O3
- CAS No.
- 380449-54-7
- Physical state
- Solid
- Color
- Off-white to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder 4°C, sealed storage, away from moisture; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO/H2O