Melflufen free base · Synonyms: Melphalan flufenamide

Melflufen (Melphalan flufenamide), a dipeptide proagent of Melphalan, is an alkylating agent.

For research use only. Not for human or veterinary use.

Target Alkylator/Crosslinker Apoptosis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

Melflufen structure

CAS No.: 380449-51-4

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 380.00	BP-02431-50mg	In stock	Get quote
100 mg	USD 605.00	BP-02431-100mg	In stock	Get quote
250 mg	USD 1,215.00	BP-02431-250mg	In stock	Get quote
500 mg	USD 1,945.00	BP-02431-500mg	In stock	Get quote
1 g	USD 3,110.00	BP-02431-1g	In stock	Get quote
2 g	USD 4,980.00	BP-02431-2g	In stock	Get quote
3 g	USD 5,970.00	BP-02431-3g	In stock	Get quote

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Related forms

BP-02431A — Melflufen hydrochloride

Description

Melflufen (Melphalan flufenamide), a dipeptide proagent of Melphalan, is an alkylating agent. Melflufen shows antitumor activity against multiple myeloma (MM) cells and inhibits angiogenesis. Melflufen induces irreversible DNA damage and cytotoxicity in MM cells .

Biological activity

In Vitro Melflufen (Melphalan flufenamide) (0.5-10 μM; 24 hours) decreases viability of MM.1S, INA-6, RPMI-8226, MM.1R, Dox-40, ARP-1, and ANBL-6 cells in a concentration-dependent manner. Melflufen induces apoptosis in MM.1S cells. Melphalan also is a potent activator of exosome secretion. In Vivo Melflufen (Melphalan flufenamide) (3 mg/kg; i.v.; twice-weekly for two weeks) shows anti-MM activity in xenograft mouse model.

Identifiers

SMILES: O=C([C@@H](NC([C@@H](N)CC1=CC=C(C=C1)N(CCCl)CCCl)=O)CC2=CC=C(C=C2)F)OCC
InChIKey: YQZNKYXGZSVEHI-VXKWHMMOSA-N

Specifications

MW (average): 498.4180
Formula: C₂₄H₃₀Cl₂FN₃O₃
CAS No.: 380449-51-4
Physical state: Oil
Color: Colorless to light yellow
Shipping: —
Storage: —

Documents

References

[1]. Chauhan D, et al. In vitro and in vivo antitumor activity of a novel alkylating agent, melphalan-flufenamide, against multiple myeloma cells. Clin Cancer Res. 2013;19(11):3019-3031.

[2]. Ray A, et al. A novel alkylating agent Melflufen induces irreversible DNA damage and cytotoxicity in multiple myeloma cells. Br J Haematol. 2016;174(3):397-409.

[3]. McAndrews KM, et, al. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer. 2019 Mar 30;18(1):52.

Same target

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Same research area

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