BRD-810 free base · Synonyms: BRD 810 · BRD810

BRD-810 is a highly selective MCL1 inhibitor.

For research use only. Not for human or veterinary use.

Target Bcl-2 Family Caspase Apoptosis

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

BRD-810 structure

CAS No.: 2329719-65-3

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 mg	USD 498.00	BP-01119-1mg	In stock	Get quote
5 mg	USD 1,150.00	BP-01119-5mg	In stock	Get quote
10 mg	USD 1,850.00	BP-01119-10mg	In stock	Get quote
25 mg	USD 2,850.00	BP-01119-25mg	In stock	Get quote
50 mg	Inquire	BP-01119-50mg	In stock	Inquire
100 mg	Inquire	BP-01119-100mg	In stock	Inquire

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Description

BRD-810 is a highly selective MCL1 inhibitor. BRD-810 shows anti-tumor activity in models of blood cancers and solid tumors.

Biological activity

BRD-810 is a highly selective MCL1 inhibitor. BRD-810 can bind to the BH3 groove of MCL1 and block the sequestration of pro-apoptotic proteins, quickly inducing caspase activation in MCL1-dependent cell lines. BRD-810 shows anti-tumor activity in models of blood cancers and solid tumors.

Identifiers

SMILES: ClC1=C2C3=C(C(CCCOC=4C5=C(C=CC4)C=C(F)C=C5)=C(C(O)=O)N3CCCCO[C@H](CCN6CCOCC6)C=7C2=C(CC)N(C)N7)C=C1
InChIKey: RQXSLNDYCDRXAC-MGBGTMOVSA-N

Specifications

MW (average): 703.2420
Formula: C₃₉H₄₄ClFN₄O₅
CAS No.: 2329719-65-3
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; 4℃ 2 years; protect from light; In solvent -20℃ 1 month;

Solubility

soluble in DMSO:

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Rauh U, et al. BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models. Nat Cancer. 2024 Oct;5(10):1479-1493.

Same target

Search Bcl-2 Family

Same research area

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