BIRT-377 free base · Synonyms: BIRT 377 · BIRT377

BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1.

For research use only. Not for human or veterinary use.

Target Integrin Interleukin Related

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

BIRT-377 structure

CAS No.: 213211-10-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 498.00	BP-02279-50mg	In stock	Get quote
100 mg	USD 780.00	BP-02279-100mg	In stock	Get quote
250 mg	USD 1,520.00	BP-02279-250mg	In stock	Get quote
500 mg	USD 2,300.00	BP-02279-500mg	In stock	Get quote
1 g	Inquire	BP-02279-1g	In stock	Inquire

Need another size or custom synthesis? Request a quote.

Description

BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1). BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders[1].

Biological activity

In Vitro BIRT 377 (20 μM, 6 h) inhibits the mRNA and protein expression of EMT-related markers ZEB2 and Vementin in HT-29 cell whem cocultured with LAD2 cell. BIRT 377 (20 μM, 24 h) inhibits the cell migration of HT-29, when cocultured with LAD2. In Vivo BIRT 377 (3-10 mg/kg, po, once daily for 14 days) inhibits the production of human IgG in hPBMC-injected mouse models, with an effect comparable to that of anti-LFA-1 antibodies.

Identifiers

SMILES: C[C@]1(C(=O)N(C(=O)N1C)C2=CC(=CC(=C2)Cl)Cl)CC3=CC=C(C=C3)Br
InChIKey: FJNJHZQMQRVZEE-GOSISDBHSA-N

Specifications

MW (average): 442.1340
Formula: C₁₈H₁₅BrCl₂N₂O₂
CAS No.: 213211-10-0
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃, 3 years; 4℃, 2 years; In solvent -20℃, 1 month;

Solubility

soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Kelly TA, et al. Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion. J Immunol. 1999;163(10):5173-5177.

[2]. Lanzloth R, et al. Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition[J]. bioRxiv, 2025: 2025.03. 19.644113.

[3]. Winquist RJ, et al., The role of leukocyte function-associated antigen-1 in animal models of inflammation. Eur J Pharmacol. 2001 Oct 19;429(1-3):297-302.

Same target

Search Integrin

Same research area

Search Inflammation/Immunology