LRH-1 modulator-1 free base
LRH-1 agonist-2 is a selective, full LRH-1 agonist.
For research use only. Not for human or veterinary use.
LRH-1 modulator-1 structure
CAS No.: 2244781-29-9
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 5 mg | USD 680.00 | BP-02170-5mg | In stock | Get quote |
| 10 mg | USD 1,150.00 | BP-02170-10mg | In stock | Get quote |
| 25 mg | USD 2,280.00 | BP-02170-25mg | In stock | Get quote |
| 50 mg | USD 3,600.00 | BP-02170-50mg | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
LRH-1 agonist-2 (Compound 6N) is a selective, full LRH-1 agonist with an EC50 of 15.7 nM. LRH-1 agonist-2 directly interacts with the Thr352 and His390 residues in the LRH-1 binding pocket, promotes allosteric signaling to the activation function surface (AFS), stabilizes the AFS and enhances coactivator recruitment. LRH-1 agonist-2 induces the anti-inflammatory cytokine IL-10, and reduces the pro-inflammatory cytokines IL-1β and TNFα. LRH-1 modulator-1 exerts anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 can be used in studies related to inflammatory bowel disease.
Biological activity
In Vitro LRH-1 modulator-1 potently activates the transcriptional activity of LRH-1 in Hela cells with an EC50 of 15.7 nM, and this activity depends on the interaction with LRH-1 residues Thr352 and His390.
Identifiers
- SMILES
-
CCCCCCC1=C([C@@]2(CC[C@@H]([C@@H]2C1)NS(=O)(=O)N)C(=C)C3=CC=CC=C3)C4=CC=CC=C4 - InChIKey
-
COQCBADNBTZWQG-NSVAZKTRSA-N
Specifications
- MW (average)
- 464.6630
- Formula
- C28H36N2O2S
- CAS No.
- 2244781-29-9
- Physical state
- Other
- Color
- Colorless to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Liquid -20℃ 3 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO : 66.67 mg/mL