phthalazinone 24 free base · Synonyms: bromophenyl phthalazinone 24 | 2085274-00-4

phthalazinone 24 is a potent Antifungal Synergy of Phthalazinone with Azoles Against Candida albicans (EC50 =1 nM).

For research use only. Not for human or veterinary use.

Target Fungal

Research area Infection

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Data Sheet SDS COA

phthalazinone 24 structure

CAS No.: 2085274-00-4

Download structure (.mol)

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Description

phthalazinone 24 is a potent Antifungal Synergy of Phthalazinone with Azoles Against Candida albicans (EC50 =1 nM).

Biological activity

In Vitro Antifungal agent 35 (compound 24) (0.0015-15 mM; C. albicans) inhibits fungal cell growth in a dose-dependent manner with EC50 value of 0.001 µM in the presence of fluconazole. Antifungal agent 35 (compound 24) (0.0015-15 mM; C. albicans) shows potent activities (EC50 < 1 μM) against all resistant isolates in the presence of fluconazole.

Identifiers

SMILES: O=C(C1=NN(C2=CC=C(C=C2OC)Br)C(C3=C1C=CC=C3)=O)NCC(NCCC4=CCCCC4)=O
InChIKey: RGMIHEWYUXSZJY-UHFFFAOYSA-N

Specifications

MW (average): 539.4210
Formula: C₂₆H₂₇BrN₄O₄
CAS No.: 2085274-00-4
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years; In solvent -20℃ 1 month;

Solubility

DMSO

Documents

References

[1]. Mood AD, et, al. Potent Antifungal Synergy of Phthalazinone and Isoquinolones with Azoles Against Candida albicans. ACS Med Chem Lett. 2017 Jan 11;8(2):168-173.

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