BAY-069 free base · Synonyms: BAY 069 · BAY069

BAY-069 is a potent branched-chain amino acid transaminases 1 and BCAT2 inhibitor.

For research use only. Not for human or veterinary use.

Target Fluorescent Dye

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

BAY-069 structure

CAS No.: 2639638-66-5

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 1,885.00	BP-02239-100mg	In stock	Get quote
250 mg	USD 2,784.00	BP-02239-200mg	In stock	Get quote
500 mg	Inquire	BP-02239-500mg	In stock	Inquire

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Related forms

BP-02239A — BAY-5000

Description

BAY-069 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC50 values of 31 nM and 153 nM, respectively. BAY-069 also can be used as a chemical probe. BAY-069 can be used tor research anticancer.

Biological activity

In Vitro BAY-069 (compound 36a) (70 nM-50 μM; 72 h) inhibits cell proliferation of U-87 and MDA-MB-231. In Vivo BAY-069 exhibits high metabolic stability after incubation with human liver microsomes (CLblood = 0.11 L/h/kg) and moderate metabolic stability after incubation with rat hepatocytes (CLblood = 1.8 L/h/kg); shows high permeability through Caco-2 cell monolayers with no hint of efflux. BAY-069 (0.3 mg/kg for i.v.; 0.6 mg/kg for p.o.; single dosage) exhibits a favorable pharmacokinetic profile after i.v. dosing with low blood clearance (CLblood), moderate volume of distribution at steady state (Vss), and intermediate terminal half-life (t1/2).

Identifiers

SMILES: CC(C=CC=C1)=C1OC2=C(Cl)C3=C(C=CC=C3)C(N4C(NC(C(F)(F)F)=CC4=O)=O)=C2
InChIKey: UNSHMXUHOHBLIQ-UHFFFAOYSA-N

Specifications

MW (average): 446.8060
Formula: C₂₂H₁₄ClF₃N₂O₃
CAS No.: 2639638-66-5
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Günther J, et al. BAY-069, a Novel (Trifluoromethyl)pyrimidinedione-Based BCAT1/2 Inhibitor and Chemical Probe. J Med Chem. 2022 Oct 19.

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