VVD-214 free base · Synonyms: VVD-133214 | RO7589831
VVD-133214 is a covalent allosteric inhibitor of WRN.
For research use only. Not for human or veterinary use.
VVD-214 structure
CAS No.: 3026500-20-6
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 480.00 | BP-00122-100mg | In stock | Get quote |
| 250 mg | USD 780.00 | BP-00122-250mg | In stock | Get quote |
| 500 mg | USD 1,180.00 | BP-00122-500mg | In stock | Get quote |
| 1 g | USD 1,680.00 | BP-00122-1g | In stock | Get quote |
| 5 g | Inquire | BP-00122-5g | Inquire | Inquire |
Need another size or custom synthesis? Request a quote.
Description
VVD-133214 is a covalent allosteric inhibitor of WRN. It selectively engages a cysteine (C727). VVD-133214 binds WRN protein cooperatively with nucleotide. VVD-133214 can be used for MSI-H cancers study.
Biological activity
VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers.
Specifications
- MW (average)
- 437.4600
- Formula
- C20H21F2N3O4S
- CAS No.
- 3026500-20-6
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO