GSK-843 free base · Synonyms: GSK'843

GSK-843 is a receptor-interacting protein kinase 3 inhibitor.

For research use only. Not for human or veterinary use.

Target RIP kinase Apoptosis

Research area Inflammation/Immunology

Purity 98+% Stock Inquire

Data Sheet SDS COA

GSK-843 structure

CAS No.: 1601496-05-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 465.00	BP-02222-25mg	In stock	Get quote
50 mg	USD 675.00	BP-02222-50mg	In stock	Get quote
100 mg	USD 975.00	BP-02222-100mg	In stock	Get quote
250 mg	USD 1,475.00	BP-02222-250mg	In stock	Get quote

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Description

GSK-843 (GSK'843) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM. GSK-843 can be used for the research of inflammation .

Biological activity

GSK-843 (3-10 μM; 18 h) induces apoptosis GSK-843 (0.3-3 μM; 18 h) suppresses TNF-induced death and virus-induced cell necrosis

Identifiers

SMILES: CC1=NN(C(=C1)C2=CN=C(C3=C2SC=C3C4=CC5=C(C=C4)SC=N5)N)C
InChIKey: BPKSNNJTKPIZKR-UHFFFAOYSA-N

Specifications

MW (average): 377.4860
Formula: C₁₉H₁₅N₅S₂
CAS No.: 1601496-05-2
Physical state: Solid
Color: Light yellow to yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 50 mg/mL

Documents

References

[1].Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.

[2].Kaiser WJ, et al. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem. 2013 Oct 25;288(43):31268-79.

Same target

Search RIP kinase

Same research area

Search Inflammation/Immunology