ART812 free base · Synonyms: ART-812 · ART 812
ART812 is an orally active DNA polymerase Polθ inhibitor.
For research use only. Not for human or veterinary use.
ART812 structure
CAS No.: 2607138-82-7
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 25 mg | USD 450.00 | BP-02035-25mg | In stock | Get quote |
| 50 mg | USD 670.00 | BP-02035-50mg | In stock | Get quote |
| 100 mg | USD 972.00 | BP-02035-100mg | In stock | Get quote |
| 250 mg | USD 1,450.00 | BP-02035-250mg | In stock | Get quote |
| 500 mg | USD 2,050.00 | BP-02035-500mg | In stock | Get quote |
| 1 g | USD 2,850.00 | BP-02035-1g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
ART812 is an orally active DNA polymerase Polθ inhibitor with an IC50 value of 7.6 nM. ART812 has an IC50 value of 240 nM for cell based microhomology-mediated end joining (MMEJ).
Biological activity
ART812 (0-40 μM) elicits Polθ inhibitor sensitivity in MDA-MB-436 SHLD2 knockout cells ART812 (100 mg/kg; p.o. daily for 76 days) shows significant tumour inhibition in rats bearing established MDA-MB-436 BRCA1/SHLD2 defective tumours (volume 250-350 mm3)
Identifiers
- SMILES
-
CN(C1=CC(Cl)=C(C=C1)F)C([C@H]2N(C3=CC(C(F)(F)F)=CC(C)=N3)C([C@H]([C@H]2O)O)=O)=O - InChIKey
-
YJJOABOMFPGRED-JYJNAYRXSA-N
Specifications
- MW (average)
- 461.7950
- Formula
- C19H16ClF4N3O4
- CAS No.
- 2607138-82-7
- Physical state
- Solid
- Color
- White to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Solubility
Soluble in DMSO : 100 mg/mL