YIL781 free base · Synonyms: YIL-781 · YIL 781
YIL781 is a potent and orally active ghrelin receptor antagonist.
For research use only. Not for human or veterinary use.
YIL781 structure
CAS No.: 875258-85-8
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 560.00 | BP-02149-100mg | In stock | Get quote |
| 250 mg | USD 1,100.00 | BP-02149-250mg | In stock | Get quote |
| 500 mg | USD 1,750.00 | BP-02149-500mg | In stock | Get quote |
| 1 g | USD 2,800.00 | BP-02149-1g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
YIL781 is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 produces a greater improvement in glucose homeostasis in rats. YIL781 inhibits the calcium response induced by ghrelin with pIC50 values of 7.90 and 8.27, respectively .
Biological activity
In Vitro YIL781 (10-300 nM) induces a concentration-dependent parallel rightward shift of the ghrelin CRC with a slight but statistically significant depression of the maximal response at 100 and 300 nM, reaching a similar agonist maximal response of approximately 90%. In Vivo YIL781 (0.1 to 5 μg/5 μl) attenuates ghrelin-induced up-regulation of the blood glucose level. The i.t. treatment with YIL781 alone does not affect the blood glucose level (F = 0.8160; P = 0.5095).
Identifiers
- SMILES
-
CC1=NC2=C(C=C(C=C2)OC3=CC=C(C=C3)F)C(=O)N1C[C@H]4CCCN(C4)C(C)C - InChIKey
-
FRKXOBMDEXCHHD-SFHVURJKSA-N
Specifications
- MW (average)
- 409.4964
- Formula
- C24H28FN3O2
- CAS No.
- 875258-85-8
- Physical state
- Solid
- Color
- Light yellow to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO