PF-06835919 free base · Synonyms: Ketohexokinase inhibitor 1

Ketohexokinase inhibitor 1 is an inhibitor of ketohexokinase.

For research use only. Not for human or veterinary use.

Target Others

Research area Metabolic Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

PF-06835919 structure

CAS No.: 2102501-84-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 610.00	BP-02144-10mg	In stock	Get quote
25 mg	USD 1,200.00	BP-02144-25mg	In stock	Get quote
50 mg	USD 1,860.00	BP-02144-50mg	In stock	Get quote
100 mg	USD 2,800.00	BP-02144-100mg	In stock	Get quote

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Description

Ketohexokinase inhibitor 1 is an inhibitor of ketohexokinase (KHK), with IC50s of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively, extracted from patent US 20170183328 A1, example 4.

Biological activity

In Vitro PF-06835919 reduces steatosis and fibrosis in human hepatocyte-non-parenchymal cell co-cultures exposed to fructose.

Identifiers

SMILES: [H][C@@]12CN(C[C@]1([H])[C@H]2CC(O)=O)C1=NC(=NC(=C1)C(F)(F)F)N1CC[C@@H]1C
InChIKey: MDUYWDNWFXSMJJ-XWLWVQCSSA-N

Specifications

MW (average): 356.3429
Formula: C₁₆H₁₉F₃N₄O₂
CAS No.: 2102501-84-6
Physical state: Solid
Color: white to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO > 100mg/mL

Documents

References

[1]. Zhang H, et al. Ketohexokinase: A central mediator of fructose-associated pathogenesis and promising therapeutic target. Pharmacological research. 2026 Aug;230:108330.

Same research area

Search Metabolic Disease