Quarfloxin free base · Synonyms: Itarnafloxin | CX 3543
Quarfloxin is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells.
For research use only. Not for human or veterinary use.
Quarfloxin structure
CAS No.: 865311-47-3
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 25 mg | USD 470.00 | BP-02091-25mg | In stock | Get quote |
| 50 mg | USD 680.00 | BP-02091-50mg | In stock | Get quote |
| 100 mg | USD 930.00 | BP-02091-100mg | In stock | Get quote |
| 250 mg | USD 2,180.00 | BP-02091-250mg | In stock | Get quote |
| 500 mg | USD 3,400.00 | BP-02091-500mg | In stock | Get quote |
| 1 g | Inquire | BP-02091-1g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
Quarfloxin is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template.
Biological activity
In Vitro Quarfloxin (CX-3543) effectively inhibits the growth of neuroblastoma cells in vitro. MNA (or high c-Myc) and wt-TP53 cell lines are found to be more sensitive to Quarfloxin. Quarfloxin and induces DNA damage, p53 signaling, cell death, and cell cycle arrest in neuroblastoma cell lines. Solution in vitro: Quarfloxin is suspended in DMSO to a stock of 10 mM.
Identifiers
- SMILES
-
O=C1C2=C3N(C=C1C(NCC[C@@H]4CCCN4C)=O)C5=CC6=CC=CC=C6C=C5OC3=C(N7CC(C8=NC=CN=C8)CC7)C(F)=C2 - InChIKey
-
WOQIDNWTQOYDLF-CGAIIQECSA-N
Specifications
- MW (average)
- 604.6733
- Formula
- C35H33FN6O3
- CAS No.
- 865311-47-3
- Physical state
- Solid
- Color
- light yellow to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Solubility
Soluble in DMSO : 5 mg/mL (8.27 mM; Need ultrasonic; Dissolution under acidic conditions (HCl adjust to pH ≈3; hygroscopic DMSO has a significant impact on product solubility, please use newly opened DMSO)