K-Ras G12C-IN-4 free base
K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C.
For research use only. Not for human or veterinary use.
K-Ras G12C-IN-4 structure
CAS No.: 2376328-55-9
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 50 mg | USD 460.00 | BP-02004-50mg | In stock | Get quote |
| 100 mg | USD 736.00 | BP-02004-100mg | In stock | Get quote |
| 250 mg | USD 1,160.00 | BP-02004-250mg | In stock | Get quote |
| 500 mg | USD 1,680.00 | BP-02004-500mg | In stock | Get quote |
| 1 g | Inquire | BP-02004-1g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
K-Ras G12C-IN-4, compound 1, is a potent Covalent Inhibitor of KRASG12C.
Biological activity
In Vitro K-Ras G12C-IN-4 (4 hours) exhibits IC50=0.219 μM for inhibition of MAPK signaling (p-ERK) in MIA PaCa-2 cells. K-Ras G12C-IN-4 (72 hours) translates to a 0.067 μM IC50 for inhibition of cellular viability in a CellTiter-Glo experiment in MIA PaCa-2 cells.
Identifiers
- SMILES
-
COC1=CC=CC2=C1CCN(C(C3=C(N(C4=C3C=C(C=C4C)Cl)CC(NC5CN(C(C=C)=O)C5)=O)C6CC6)=O)C2 - InChIKey
-
JESBUJUEMLEHDQ-UHFFFAOYSA-N
Specifications
- MW (average)
- 561.0710
- Formula
- C31H33ClN4O4
- CAS No.
- 2376328-55-9
- Physical state
- Solid
- Color
- white to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Solubility
Soluble in DMSO : 60 mg/mL (111.35 mM; Need ultrasonic(<60℃); hygroscopic DMSO has a significant impact on product solubility, please use newly opened DMSO)