DCC-3116 free base · Synonyms: DCC 3116 · DCC3116

DCC-3116 is an orally active ULK1/2 inhibitor.

For research use only. Not for human or veterinary use.

Target ULK Ras Autophagy

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

DCC-3116 structure

CAS No.: 2543673-19-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
50 mg	USD 545.00	BP-02028-50mg	In stock	Get quote
100 mg	USD 820.00	BP-02028-100mg	In stock	Get quote
250 mg	USD 1,450.00	BP-02028-250mg	In stock	Get quote
500 mg	USD 1,980.00	BP-02028-500mg	In stock	Get quote
1 g	USD 2,860.00	BP-02028-1g	In stock	Get quote

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Description

DCC-3116 is an orally active ULK1/2 inhibitor. DCC-3116 can promote autophagy in lung cancer cells by inhibiting KRASG12C signaling, thereby inhibiting the proliferation of lung cancer cells and exerting anti-cancer effects.

Biological activity

In Vivo DCC-3116 (3 or 30 mg/kg/day for 56 days, p.o. and p.i.) alone or in combination with Sotorasib (HY-114277) can inhibit tumor growth in mouse models of NSCLC lung cancer. In Vitro DCC-3116 (100 nM, 72 h) alone inhibits the proliferation of NCI-H2122 and Calu-1 cells, decreases the expression of pS318-ATG13, and has a synergistic effect when combined with Sotorasib (HY-114277).

Identifiers

SMILES: O=C[1]N(CCCNC[13]()=NC(NC[24]()=CC=C(N[32]CCN(CC@32)C)C=C@24CC)=NC=C@13C(F)(F)F)CCOCC@2

Specifications

MW (average): 535.6049
Formula: C₂₆H₃₆F₃N₇O₂
CAS No.: 2543673-19-2
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO : 100 mg/mL

Documents

References

[1]. Ghazi PC, et al. Inhibition of ULK1/2 and KRAS G12C controls tumor growth in preclinical models of lung cancer. bioRxiv [Preprint]. 2024 Feb 8:2024.02.06.579200.

Same target

Search ULK

Same research area

Search Cancer