ZN-c3 free base · Synonyms: Azenosertib | ZN-c3(Compound 16)
ZN-c3 is an orally active, highly potent and selective Wee1 inhibitor.
For research use only. Not for human or veterinary use.
ZN-c3 structure
CAS No.: 2376146-48-2
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 250 mg | USD 520.00 | BP-02003-250mg | In stock | Get quote |
| 500 mg | USD 850.00 | BP-02003-500mg | In stock | Get quote |
| 1 g | USD 1,280.00 | BP-02003-1g | In stock | Get quote |
| 5 g | Inquire | BP-02003-5g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
ZN-c3 (Azenosertib) is an orally active, highly potent and selective Wee1 inhibitor (IC50=3.9 nM). ZN-c3 can be used for the research of cancer.
Biological activity
In Vitro Azenosertib inhibits proliferations of cancer cells H23 and A427 with IC50s 103 and 75 nM. In Vivo Azenosertib (80 mg/kg; p.o.; 28 days) inhibits tumor growth in A427 xenograft NOD/SCID mice model. Azenosertib (10 mg/kg, p.o.) shows plasma exposure Cmax of 2.1 μM, a half-time T1/2 of 2.3 h, an AUC0-24 h of 9.7 μM·h, and an oralbioavailability of F=142% in beagle dog model.
Identifiers
- SMILES
-
C=CCN1N(C2=CC=C(CC[C@]3(O)CC)C3=N2)C4=NC(NC5=CC=C(N6CCN(CC6)C)C=C5)=NC=C4C1=O - InChIKey
-
OXTSYWDBUVRXFF-GDLZYMKVSA-N
Specifications
- MW (average)
- 526.6327
- Formula
- C29H34N8O2
- CAS No.
- 2376146-48-2
- Physical state
- Solid
- Color
- Light yellow to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO 175 mg/mL