TAK-041 free base · Synonyms: Zelatriazin | NBI-1065846

TAK-041 is a potent and selective GPR139 agonist.

For research use only. Not for human or veterinary use.

Target GPR139

Research area Neurological Disease

Purity >98% Stock Inquire

Data Sheet SDS COA

TAK-041 structure

CAS No.: 1929519-13-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
1 g	USD 880.00	BP-01950-1g	In stock	Get quote
2 g	Inquire	BP-01950-2g	In stock	Inquire
5 g	Inquire	BP-01950-5g	Inquire	Inquire

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Description

TAK-041 (Zelatriazin; NBI-1065846) is a potent and selective GPR139 agonist with an EC50 of 22 nM. TAK-041 has the potential for the research of negative symptoms associated with schizophrenia .

Biological activity

In Vivo Zelatriazin (0.03-3 mg/kg; P.o.) improves social behavior in BALB/c mice[1].

Identifiers

SMILES: O=C(N[C@H](C1=CC=C(OC(F)(F)F)C=C1)C)CN2N=NC3=CC=CC=C3C2=O
InChIKey: JZGLECLGVQRPPI-NSHDSACASA-N

Specifications

MW (average): 392.3319
Formula: C₁₈H₁₅F₃N₄O₃
CAS No.: 1929519-13-0
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃ 2 years; -20℃ 3 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO 100 mg/mL

Documents

References

[1]. Reichard, Holly A et al. “Discovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with Schizophrenia. Journal of medicinal chemistry vol. 64,15 (2021): 11527-11542.

Same research area

Search Neurological Disease