GNE-8505 free base · Synonyms: GNE 8505 · GNE8505
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase.
For research use only. Not for human or veterinary use.
GNE-8505 structure
CAS No.: 1620573-48-9
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 10 mg | USD 420.00 | BP-01907-10mg | In stock | Get quote |
| 25 mg | USD 650.00 | BP-01907-25mg | In stock | Get quote |
| 50 mg | USD 920.00 | BP-01907-50mg | In stock | Get quote |
| 100 mg | USD 1,320.00 | BP-01907-100mg | In stock | Get quote |
| 250 mg | USD 2,120.00 | BP-01907-250mg | In stock | Get quote |
| 500 mg | Inquire | BP-01907-500mg | In stock | Inquire |
| 1 g | Inquire | BP-01907-1g | Inquire | Inquire |
Need another size or custom synthesis? Request a quote.
Description
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK) .
Biological activity
In Vivo GNE-8505 (3-18 mg/kg; p.o.; single administration) rapidly and dose-dependently reduces injury-induced phosphorylated c-Jun levels in the retina of mice, with an in vivo IC50 of 0.98 μM. Single administration of GNE-8505 (35 mg/kg) significantly reduces the number of phosphorylated c-Jun-positive cells in the spinal cord of SOD1G93A ALS mice at the middle stage of the disease.
Identifiers
- SMILES
-
FC(F)(F)C1=CC(C2=NN(C([C@@H]3[C@]4([H])[C@@]3([H])CN(C5COC5)C4)=C2)CC6CC6)=CN=C1N - InChIKey
-
IRPVABHDSJVBNZ-QWHZDKJVSA-N
Specifications
- MW (average)
- 419.4434
- Formula
- C21H24F3N5O
- CAS No.
- 1620573-48-9
- Physical state
- Solid
- Color
- white to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month
Solubility
Soluble in DMSO : 100 mg/mL