S55746 free base · Synonyms: S55746 free base | BLC-201
S55746 is a potent, orally active and selective BCL-2 inhibitor.
For research use only. Not for human or veterinary use.
Target
Bcl-2 Family
Research area
Cancer
Purity >98%
Stock Inquire
Description
S55746 (BLC201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BLC201) has antitumor activity with low toxicity.
Biological activity
S55746 (BCL201) is a potent, orally active and selective BCL-2 inhibitor, with a Ki of 1.3 nM and a Kd of 3.9 nM. S55746 (BCL201) has antitumor activity with low toxicity.
Identifiers
- SMILES
-
O=C(C1=C2CCCCN2C(C3=C(C(N4CC5=C(C=CC=C5)C[C@H]4CN6CCOCC6)=O)C=C(OCO7)C7=C3)=C1)N(C8=CC=C(O)C=C8)C9=CC=CC=C9 - InChIKey
-
VYXJULKGMXJVGI-XIFFEERXSA-N
Specifications
- MW (average)
- 710.8168
- Formula
- C43H42N4O6
- CAS No.
- 1448584-12-0
- Physical state
- Solid
- Color
- White to light yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO
- In vitro
- DMSO : 75 mg/mL
Documents
References
[1] Casara P, et al. S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth. Oncotarget. 2018, 9(28):20075-20088.