Opiranserin hydrochloride salt form · hydrochloride · Parent Opiranserin hydrochloride · Synonyms: VVZ-149 hydrochloride
Opiranserin hydrochloride, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2.
For research use only. Not for human or veterinary use.
Opiranserin hydrochloride structure
CAS No.: 1440796-75-7
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 25 mg | USD 685.00 | BP-02246A-25mg | In stock | Get quote |
| 50 mg | USD 985.00 | BP-02246A-50mg | In stock | Get quote |
| 100 mg | USD 1,385.00 | BP-02246A-100mg | In stock | Get quote |
| 200 mg | USD 2,185.00 | BP-02246A-200mg | In stock | Get quote |
| 500 mg | USD 3,985.00 | BP-02246A-500mg | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
Opiranserin (VVZ-149) hydrochloride, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin hydrochloride shows antagonistic activity on rP2X3 (IC50=0.87 μM).
Biological activity
Opiranserin hydrochloride (25 mg/kg, s.c.) effectively reduced mechanical allodynia and pain-related behaviors with efficacy comparable to 3 mg/kg Morphine Opiranserin hydrochloride (80 mg/kg, p.o.) reduced mechanical allodynia in a rat spinal nerve ligation model
Identifiers
- SMILES
-
O=C(C1=CC(OC)=C(OCCCC)C(OC)=C1)NCC2(CCOCC2)N(C)C.[H]Cl - InChIKey
-
GSCGQHXDHYVKOL-UHFFFAOYSA-N
Specifications
- MW (average)
- 430.9660
- Formula
- C21H35ClN2O5
- CAS No.
- 1440796-75-7
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- 4°C, sealed storage, away from moisture
Solubility
Soluble in DMSO
- In vitro
- DMSO : 50 mg/mL