NSD1 inhibitor BT5 free base · Synonyms: BT5

NSD-IN-2 is a potent and irreversible NSD1 inhibitor.

For research use only. Not for human or veterinary use.

Target Histone Methyltransferase

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

NSD1 inhibitor BT5 structure

CAS No.: 2351225-46-0

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 725.00	BP-02238-10mg	In stock	Get quote
25 mg	USD 1,050.00	BP-02238-25mg	In stock	Get quote
50 mg	USD 1,658.00	BP-02238-50mg	In stock	Get quote
100 mg	USD 2,688.00	BP-02238-2g	In stock	Get quote
250 mg	Inquire	BP-02238-250mg	In stock	Inquire
500 mg	Inquire	BP-02238-5g	In stock	Inquire

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Description

NSD-IN-2 (compound 151) is a potent and irreversible NSD1 inhibitor. NSD-IN-2 can be used in research of cancer.

Biological activity

In Vitro NSD-IN-2 (Compound 151) (10 μM, 20 h) forms a covalent protein adduct with NSD1. NSD-IN-2 rdecresaes H3K36me2 recruitment on KLF9 promoter in chondrocytes.

Identifiers

SMILES: OC1=C2N=C(N)SC2=CC(N3C(C)C3)=C1
InChIKey: PHBIAWCGMOCBGF-UHFFFAOYSA-N

Specifications

MW (average): 221.2790
Formula: C₁₀H₁₁N₃OS
CAS No.: 2351225-46-0
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 3 years, 4°C 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 100 mg/mL

Documents

References

[1]. Tomasz C, et, al. Nsd family inhibitors and methods of treatment therewith. US20190183865A1.

[2]. Yang Q, et al. Nuclear binding SET domain 1 alleviates cartilage ferroptosis in knee osteoarthritis by upregulating the krüppel-like factor 9/autophagy-related 14 pathway via H3K36me2 modification. J Cell Commun Signal. 2025 Jun 29;19(3):e70027.

Same target

Search Histone Methyltransferase

Same research area

Search Cancer