LLY-283 free base · Synonyms: LLY 283 · LLY283
LLY-283 is an effective and selective inhibitor of protein arginine methyltransferase 5.
For research use only. Not for human or veterinary use.
LLY-283 structure
CAS No.: 2040291-27-6
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 425.00 | BP-01962-100mg | In stock | Get quote |
| 250 mg | USD 808.00 | BP-01962-250mg | In stock | Get quote |
| 500 mg | USD 1,295.00 | BP-01962-500mg | In stock | Get quote |
| 1 g | USD 2,075.00 | BP-01962-1g | In stock | Get quote |
| 5 g | Inquire | BP-01962-5g | Inquire | Inquire |
Need another size or custom synthesis? Request a quote.
Description
LLY-283 is an effective and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) (IC50: 22 nM and a Kd: 6 nM for PRMT5:MEP50 complex). It shows antitumor activity.
Biological activity
In Vitro LLY-283 is a potent, oral and selective arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM in vitro and 25 nM in cells, as well as a Kd of 6 nM for PRMT5:MEP50 complex in vitro; LLY-283 inhibits the proliferation of A375 cell with an IC50 of 46 nM. In Vivo LLY-283 (20 mg/kg; p.o., QD (once a day)) causes a significant inhibition on tumor growth in mice bearing A375 cells after treatment for 28 days.
Identifiers
- SMILES
-
C1=CC=C(C=C1)[C@H]([C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C(N=CN=C43)N)O)O)O - InChIKey
-
WWOOWAHTEXIWBO-QFRSUPTLSA-N
Specifications
- MW (average)
- 342.3492
- Formula
- C17H18N4O4
- CAS No.
- 2040291-27-6
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO