BAY-218 free base · Synonyms: AHR antagonist 1
BAY-218 is an aryl hydrocarbon receptor antagonist.
For research use only. Not for human or veterinary use.
BAY-218 structure
CAS No.: 2162982-11-6
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 250 mg | USD 420.00 | BP-01978-250mg | In stock | Get quote |
| 500 mg | USD 608.00 | BP-01978-500mg | In stock | Get quote |
| 1 g | USD 882.00 | BP-01978-1g | In stock | Get quote |
| 5 g | Inquire | BP-01978-5g | Inquire | Inquire |
Need another size or custom synthesis? Request a quote.
Description
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist. BAY-218 has AHR inhibitory activity with an IC50 of 39.9 nM in in U87 glioblastoma cells. BAY-218 can be used for the research of cancer or conditions with dysregulated immune responses.
Biological activity
In Vitro BAY-218 (example 23) (72 pM-20 μM) has AHR inhibitory activity with an IC50 of 39.9 μM in in U87 glioblastoma cells. ? BAY-218 (1 nM-3 μM) has CYP1A1 inhibitory activity with an IC50 of 70.7 μM in human monocytic U937 cell line. ? BAY-218 (1 μM) reverses KA-induced inhibition of TNFα production by LPS stimulated human monocytes. In Vivo BAY-218 (example 23) (p.o; 30 mg/kg; bid) has good anti-tumor effect combinated with aPD-L1.
Identifiers
- SMILES
-
O=C(C1=CC(C2=CC=C(Cl)C=C2)=NN(C3=CC=CC(F)=C3)C1=O)N[C@@H](C)CO - InChIKey
-
RFGRNBWAUZSMBN-LBPRGKRZSA-N
Specifications
- MW (average)
- 401.8190
- Formula
- C20H17ClFN3O3
- CAS No.
- 2162982-11-6
- Physical state
- Solid
- Color
- light yellow to yellow
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder 4℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO