Mevrometostat free base · Synonyms: PF-06821497

PF-06821497 is a potent, selective and orally active Enhancer of Zeste Homolog 2 inhibitor.

For research use only. Not for human or veterinary use.

Purity >98% Stock Inquire

Data Sheet SDS COA

Mevrometostat structure

CAS No.: 1844849-10-0

Pack sizes & pricing

Size	Price	SKU	Stock
25 mg	USD 425.00	BP-01935-25mg	In stock	Get quote
50 mg	USD 695.00	BP-01935-50mg	In stock	Get quote
100 mg	USD 1,125.00	BP-01935-100mg	In stock	Get quote
250 mg	USD 1,725.00	BP-01935-250mg	In stock	Get quote
500 mg	Inquire	BP-01935-500mg	In stock	Inquire
1 g	Inquire	BP-01935-1g	In stock	Inquire

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Description

PF-06821497 (compound 23a) is a potent, selective and orally active Enhancer of Zeste Homolog 2 (EZH2) inhibitor, with a Ki value <0.1 nM against mutant Y641N EZH2. Exhibits robust tumor growth inhibition.

Identifiers

SMILES: CC1=CC(=C(C(=O)N1)CN2CCC3=C(C=C(C(=C3C2=O)Cl)[C@@H](C4COC4)OC)Cl)OC
InChIKey: RXCVUHMIWHRLDF-HXUWFJFHSA-N

Specifications

MW (average): 467.3420
Formula: C₂₂H₂₄Cl₂N₂O₅
CAS No.: 1844849-10-0
Physical state: Solid
Color: White to off-white
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder 4℃, 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

Documents

References

[1]. Kung PP, et al. Optimization of Orally Bioavailable Enhancer of Zeste Homolog 2 (EZH2) Inhibitors Using Ligand and Property-Based Design Strategies: Identification of Development Candidate (R)-5,8-Dichloro-7-(methoxy(oxetan-3-yl)methyl)-2-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one (PF-06821497). J Med Chem. 2018 Feb 8;61(3):650-665.