KN-92 phosphate salt form · phosphate (1:1) · Parent KN-93 · Synonyms: KN92 phosphate| KN 92 phosphate

KN-92 KN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity.

For research use only. Not for human or veterinary use.

Target CaMK

Area Cancer

Purity >98% Stock In stock

Data Sheet SDS COA

KN-92 phosphate structure

CAS No.: 1135280-28-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 42.00	BP-00001A-10mg	In stock	Get quote
25 mg	USD 65.00	BP-00001A-25mg	In stock	Get quote
1 g	USD 300.00	BP-00001A-1g	In stock	Get quote
10 mg ≥99%	USD 55.00	BP-00001A-10mg-p99	In stock	Get quote
25 mg ≥99%	USD 80.00	BP-00001A-25mg-p99	In stock	Get quote
1 g ≥99%	USD 450.00	BP-00001A-1g-p99	In stock	Get quote

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Related forms

BP-00001 — KN-92

Description

KN-92 KN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor[1][2].is an inactive derivative of KN-93, without CaM kinase inhibitory activity.

Biological activity

KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50 μM; 24 hours) is ineffective in blocking cell growth[2]. The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduces the expression of p53 and p21[2].

Identifiers

SMILES: OP(O)(O)=O.COC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=C1CN(C)C\C=C\C1=CC=C(Cl)C=C1

Specifications

MW (average): 554.9800
Formula: C₂₄H₂₈ClN₂O₇PS
CAS No.: 1135280-28-2
Physical state: Solid
Color: White to off-white
Shipping: Room temperature in continental US; may vary elsewhere.
Storage: 4°C, sealed storage, away from moisture; * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Documents

References

[1]. Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277(38):35061-35070.

[2]. An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13(9):1445-1448.