KN-92 free base · Parent KN-93 · Synonyms: KN92 | KN 92

KN-92 is anKN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity.

For research use only. Not for human or veterinary use.

Target CaMK

Area Cancer

Purity >98% Stock In stock

Data Sheet SDS COA

KN-92 structure

CAS No.: 176708-42-2

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 42.00	BP-00001-10mg	In stock	Get quote
25 mg	USD 65.00	BP-00001-25mg	In stock	Get quote
1 g	USD 300.00	BP-00001-1g	In stock	Get quote
5 g	Inquire	BP-00001-5g	In stock	Inquire

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Related forms

BP-00001A — KN-92 phosphate

Description

KN-92 is anKN-92 is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor[1][2]. inactive derivative of KN-93, without CaM kinase inhibitory activity.

Biological activity

KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50 μM; 24 hours) is ineffective in blocking cell growth[2]. The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduces the expression of p53 and p21[2].

Identifiers

SMILES: COC1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC=C1CN(C)C\C=C\C1=CC=C(Cl)C=C1

Specifications

MW (average): 456.9850
Formula: C₂₄H₂₅ClN₂O₃S
CAS No.: 176708-42-2
Physical state: Solid
Color: White to off-white
Shipping: Room temperature in continental US; may vary elsewhere.
Storage: Powder -20°C 3 years; 4°C 2 years; In solvent -80°C 6 months; -20°C 1 month

Documents

References

[1]. Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277(38):35061-35070.

[2]. An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13(9):1445-1448.