Pyridostain free base
Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM).
For research use only. Not for human or veterinary use.
Description
Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM). Pyridostatin promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin targets the proto-oncogene Src. Pyridostatin reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells.
Biological activity
In Vitro Pyridostatin (RR82) (10 μM; 48 hours) induces cell cycle arrest. Pyridostatin is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin induces the formation of DNA DSBs. Remarkably, Pyridostatin (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level.
Identifiers
- SMILES
-
NCCOC1=CC(=NC(=C1)C(=O)NC1=NC2=CC=CC=C2C(OCCN)=C1)C(=O)NC1=NC2=CC=CC=C2C(OCCN)=C1 - InChIKey
-
VGHSATQVJCTKEF-UHFFFAOYSA-N
Specifications
- MW (average)
- 596.6364
- Formula
- C31H32N8O5
- CAS No.
- 1085412-37-8
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO