M3541 free base · Synonyms: M-3541 · M 3541

M3541 is a potent, ATP-competitive and selective ATM inhibitor.

For research use only. Not for human or veterinary use.

Target ATM/ATR

Research area Cancer

Purity >98% Stock Inquire

Data Sheet SDS COA

M3541 structure

CAS No.: 1360628-91-6

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
100 mg	USD 750.00	BP-02256-100mg	In stock	Get quote
250 mg	USD 1,250.00	BP-02256-250mg	In stock	Get quote
500 mg	USD 1,785.00	BP-02256-500mg	In stock	Get quote
1 g	USD 2,285.00	BP-02256-1g	In stock	Get quote
3 g	Inquire	BP-02256-3g	In stock	Inquire
5 g	Inquire	BP-02256-5g	In stock	Inquire

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Description

M3541 is a potent, ATP-competitive and selective ATM inhibitor with an IC50 of 0.25 nM. M3541 shows remarkable selectivity against other protein kinases. M3541 suppresses double-strand breaks (DSB) repair and has antitumor activities.

Biological activity

M3541 is a potent, ATP-competitive and selective ATM inhibitor with an IC50 of 0.25 nM.

Identifiers

SMILES: N#CC1=CC=C(N(C2=C3C=NC4=CC(OC)=C(C5=CN(C)N=C5)C=C24)C(N3C)=O)C(F)=C1
InChIKey: OOCGUVCGJIUQKC-UHFFFAOYSA-N

Specifications

MW (average): 428.4185
Formula: C₂₃H₁₇FN₆O₂
CAS No.: 1360628-91-6
Physical state: Solid
Color: White to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -20°C, 1 month

Solubility

Soluble in DMSO

In vitro: DMSO : 4.55 mg/mL

Documents

References

[1]. Astrid Zimmermann, et al. A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies. Mol Cancer Ther. 2022 Jun 1;21(6):859-870.

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