HOIPIN-8 sodium salt form · sodium · Parent HOIPIN-8 sodium · Synonyms: HOIPIN-8 sodium salt

HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex.

For research use only. Not for human or veterinary use.

Target E1/E2/E3 Enzyme

Research area Inflammation/Immunology

Purity >98% Stock Inquire

Data Sheet SDS COA

HOIPIN-8 sodium structure

CAS No.: 2519537-70-1

Download structure (.mol)

Pack sizes & pricing

Size	Price	SKU	Stock
10 mg	USD 400.00	BP-02248A-10mg	In stock	Get quote
25 mg	USD 785.00	BP-02248A-25mg	In stock	Get quote
50 mg	USD 1,083.00	BP-02248A-50mg	In stock	Get quote
100 mg	USD 1,585.00	BP-02248A-100mg	In stock	Get quote
200 mg	USD 2,285.00	BP-02248A-200mg	In stock	Get quote
1 g	Inquire	BP-02248A-1g	In stock	Inquire

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Description

HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC.

Biological activity

In Vitro HOIPIN-8 (0-100 μM; 72 hours) has little cell toxicity on A549 cells, and exhibits an IC50 value of 100 μM. HOIPIN-8 (0-10 μM; 24 hours) has an inhibitory effect over 10-fold enhancement over that of HOIPIN-1 on NF-κB activation, exhibits an IC50 value of 0.42 μM in HEK293T cells. HOIPIN-8 (0-30 μM; NF-κB luciferase reporter is transfected into cells for 18 hours; then with 10 ng/ml TNF-α for 6 h) exhibits a 4-fold enhancements of the potency than HOIPIN-1, the IC50 value is 11.9 μM. It also effectively reduces IL-1β-induced expression of NF-κB target genes, such as ICAM1 and IL-6 as compared to HOIPIN-1.

Identifiers

SMILES: O=C(O[Na])C1=CC=C(C2=CN(C)N=C2)C=C1/C=C/C(C3=C(F)C=C(C4=CNN=C4)C=C3F)=O
InChIKey: DLJPWYFLGYVMKV-WGCWOXMQSA-M

Specifications

MW (average): 456.3768
Formula: C₂₃H₁₅F₂N₄NaO₃
CAS No.: 2519537-70-1
Physical state: Solid
Color: Off-white to light yellow
Shipping: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage: Powder -20℃ 2 years; In solvent -20℃ 1 month;

Solubility

Soluble in DMSO

In vitro: DMSO : 50 mg/mL

Documents

References

[1]. Ken Katsuya, et al. Small-molecule Inhibitors of Linear Ubiquitin Chain Assembly Complex (LUBAC), HOIPINs, Suppress NF-κB Signaling. Biochem Biophys Res Commun. 2019 Feb 12;509(3):700-706.

Same target

Search E1/E2/E3 Enzyme

Same research area

Search Inflammation/Immunology