GSK805 free base · Synonyms: GSK-805 · GSK 805
GSK805 is an orally active and CNS penetrant RORγt inhibitor.
For research use only. Not for human or veterinary use.
GSK805 structure
CAS No.: 1426802-50-7
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 100 mg | USD 420.00 | BP-02142-100mg | In stock | Get quote |
| 250 mg | USD 800.00 | BP-02142-250mg | In stock | Get quote |
| 500 mg | USD 1,280.00 | BP-02142-500mg | In stock | Get quote |
| 1 g | USD 2,100.00 | BP-02142-1g | In stock | Get quote |
| 2 g | USD 3,200.00 | BP-02142-2g | In stock | Get quote |
| 3 g | USD 3,980.00 | BP-02142-3g | In stock | Get quote |
Need another size or custom synthesis? Request a quote.
Description
GSK805 is an orally active and CNS penetrant RORγt inhibitor. GSK805 inhibits RORγ and Th17 cells differentiation with pIC50 values of 8.4 and >8.2. GSK805 inhibits the function of Th17 cells. GSK805 can be used for the research of immunity .
Biological activity
In Vitro GSK805 (0.5 μM; 4 d) inhibits Th17 cell responses. In Vivo GSK805 (10 mg/kg; p.o. once per day for 35 days) improves the situation of mice with experimental autoimmune encephalomyelitis (EAE). GSK805 (30 mg/kg) inhibits Th17 cell responses in EAE mice.
Identifiers
- SMILES
-
CCS(=O)(=O)C1=CC=C(CC(=O)NC2=CC(Cl)=C(C(Cl)=C2)C2=CC=CC=C2OC(F)(F)F)C=C1 - InChIKey
-
CEICQMBWAQAIQX-UHFFFAOYSA-N
Specifications
- MW (average)
- 532.3600
- Formula
- C23H18Cl2F3NO4S
- CAS No.
- 1426802-50-7
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; 4℃ 2 years; In solvent -20℃ 1 year;
Solubility
Soluble in DMSO