SAGE-718 free base · Synonyms: Dalzanemdor
Dalzanemdor is an NMDA receptor-positive modulator of metabolism.
For research use only. Not for human or veterinary use.
SAGE-718 structure
CAS No.: 1629853-48-0
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 1 mg | USD 420.00 | BP-01913-1mg | In stock | Get quote |
| 5 mg | USD 780.00 | BP-01913-5mg | In stock | Get quote |
| 10 mg | USD 1,080.00 | BP-01913-10mg | In stock | Get quote |
| 25 mg | USD 1,480.00 | BP-01913-25mg | In stock | Get quote |
| 50 mg | USD 2,080.00 | BP-01913-50mg | In stock | Get quote |
| 100 mg | USD 2,980.00 | BP-01913-100mg | In stock | Get quote |
| 250 mg | Inquire | BP-01913-250mg | In stock | Inquire |
| 500 mg | Inquire | BP-01913-500mg | Inquire | Inquire |
Need another size or custom synthesis? Request a quote.
Description
Dalzanemdor (SAGE-718) is an NMDA receptor-positive modulator of metabolism that can be used to study Huntington's chorea, Alzheimer's disease, and cognitive dysfunction.
Biological activity
In vivo SAGE-718 (Dalzanemdor) (5), a potent and high intrinsic activity NMDAR PAM with an optimized pharmacokinetic profile for oral dosing. Compound 5 has completed phase 1 single ascending dose and multiple ascending dose clinical trials and is currently undergoing phase 2 clinical trials for the treatment of cognitive impairment in Huntington's disease.
Identifiers
- SMILES
-
C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CC[C@](C(F)(F)F)(C)O)C)(CC4)[H])[H])(CC=C1C[C@@](C)(O)CC2)[H])[H] - InChIKey
-
BVBRUQYHUXKZMQ-JNVAYQLDSA-N
Specifications
- MW (average)
- 456.6243
- Formula
- C27H43F3O2
- CAS No.
- 1629853-48-0
- Physical state
- Solid
- Color
- White to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 2 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO