Taminadenant free base · Synonyms: NIR178 | PBF509
Taminadenant is a highly potent and orally active adenosine A2A receptor antagonist.
For research use only. Not for human or veterinary use.
Taminadenant structure
CAS No.: 1337962-47-6
Pack sizes & pricing
| Size | Price | SKU | Stock | |
|---|---|---|---|---|
| 1 g | USD 398.00 | BP-01018-1g | In stock | Get quote |
| 2 g | USD 650.00 | BP-01018-2g | In stock | Get quote |
| 5 g | USD 1,585.00 | BP-01018-5g | In stock | Get quote |
| 10 g | Inquire | BP-01018-10g | In stock | Inquire |
| 20 g | Inquire | BP-01018-20g | In stock | Inquire |
Need another size or custom synthesis? Request a quote.
Description
Taminadenant (NIR178; PBF509) is a highly potent and orally active adenosine A2A receptor (A2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 nM and 8.2 nM, respectively.
Biological activity
Taminadenant (NIR178; PBF509) is a highly potent and orally active adenosine A2A receptor (A2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparkinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab. Taminadenant reactivate the antitumor immune response.
Identifiers
- SMILES
-
BrC(C(N1C=CC=N1)=NC(N2C=CC=N2)=N3)=C3N - InChIKey
-
ATFXVNUWQOXRRU-UHFFFAOYSA-N
Specifications
- MW (average)
- 306.1210
- Formula
- C10H8BrN7
- CAS No.
- 1337962-47-6
- Physical state
- Solid
- Color
- white to off-white
- Shipping
- Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
- Storage
- Powder -20℃ 3 years; In solvent -20℃ 1 month;
Solubility
Soluble in DMSO
- In vitro
- DMSO : 125 mg/mL